After a two year cross-disciplinary consultation process the Coordinating Action Systems Medicine (CASyM) published its European implementation strategy (roadmap) for Systems Medicine. The vision of this roadmap is to develop Systems Medicine into a practical framework that assists clinical decision making and the design of personalised prevention and treatment plans. Central to this is a systems approach that addresses clinical questions and provides solutions to the most pressing clinical challenges such as the results of an ageing population, increased needs for social care and a growing burden of curing and caring for patients with cancer.